Leaderboard Ad

Research Looks at ISSNHL, Tinnitus, Dizziness, and Vertigo

Two speakers from Hospital Universitario de Fuenlabrada, Madrid, Spain, discuss their presentations Tuesday during Scientific Oral Presentations: Otology/Neurotology.

Two speakers from Hospital Universitario de Fuenlabrada, Madrid, Spain, discuss their presentations Tuesday during Scientific Oral Presentations: Otology/Neurotology.

Twelve presentations took interesting looks at research into sudden hearing loss, tinnitus, dizziness, and vertigo Tuesday during “Scientific Oral Presentations: Otology/Neurotology.”

Stem Cells Within PGAt Observed In Vivo After Six Weeks Enhance Facial Nerve Regeneration

The functional and histological effects of bone marrow stem cells (BMSC) combined with polyglycolic acid tube (PGAt) in autografted rat facial nerves was examined in study at the University of Sao Paulo, Brazil. A secondary objective was to evaluate the presence and phenotype of the exogenous cells in the autografted nerves, six weeks after implantation.

The regeneration of facial nerves was improved by BMSC within PGAt in rats, yet Schwann-like cells were associated with superior effects. Two of the groups followed had BMSC integrated in neural tissue with maintenance of former cell phenotype for six weeks.

Antivirals for Idiopathic Sudden Sensorineural Hearing Loss

A study to assess the effectiveness of antivirals in improving hearing and reducing tinnitus, and determining the effects of medications was the subject of a Cochrane Collaboration Database Systematic Review.

The study started with 52 abstracts and was finally based on four abstracts published from 1998 to 2003. Researchers found no statistically significant advantage in the use of antivirals for treatment of idiopathic sudden sensorineural hearing loss (ISSNHL), said a presenter from the Royal National Throat, Nose, and Ear Hospital, London. He also added that the only successful treatment has been the use of hyperbaric oxygen.

Intratympanic Corticoid After High-Dose Intravenous Methylprednosolone in ISSNHL

Another study of sudden hearing loss investigated the therapeutic efficacy of intratympanic methylprednisolone after systemic corticosteroid treatment in patients with ISSNHL. The retrospective trial at Hospital Universitario de Fuenlabrada, Madrid, Spain, included 104 patients.

Researchers concluded that intravenous corticosteroid treatment shows a significant hearing improvement in severe ISSNHL in comparison to oral treatment in mild to moderate cases. They also reported that intratympanic steroids used as a rescue after failed systemic therapy promote a higher hearing recovery and that intratympanic steroids provide a safe and effective therapeutic option.

Transcranial Magnetic Stimulation as a Treatment for Tinnitus

Transcranial magnetic stimulation (TMS) is an FDA-approved treatment for depression, and an experimental treatment for movement disorders, chronic pain, stroke and other conditions. The National Center for Rehabilitative Auditory Research at the Portland VA Medical Center studied its use for tinnitus because imaging studies show that tinnitus is often associated with superfluous activity in the auditory system.

In a study using both active treatment and a placebo, those in the active trial had a 33 percent decrease in their Tinnitus Functional Index scores at 26 weeks while those in the placebo group had no change.

Although results from the trial are encouraging, additional participants should be enrolled to address and clarify some procedural issues, the presenter said.

Surgical Results of Middle Ear Tendon Resection for Middle Ear Myoclonic Tinnitus

The success of surgery on middle ear tendons to treat tinnitus was reviewed by a surgeon from the Department of Otolaryngology-HNS, Seoul St. Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul.

The surgery was performed on 22 patients diagnosed with middle ear myoclonus (MEM) and involved the resection of the middle ear tendons. The study concluded that sectioning of the tendons “seems to be safe and effective, which can be considered to be a promising treatment modality for intractable MEM tinnitus.”

Central Auditory Gain Secondary to Hearing Deprivation and its Role in Hyperacusis

The use of hearing deprivation to produce higher sensitivity perceived as hyperacusis in normal hearing subjects was the examined in a study at the Universidad Central de Venezuela Luis Razetti School of Medicine, Department of Otolaryngology and the Fundación Venezolana de Otologí­a Clinical Research Group.

The researchers also hypothesized that hyperacusis is derived from deprivation and is regulated by central auditory gain in the auditory cortex, and will be affected by cortical sleep pattern and circadian cycle.

The study found that normal hearing subjects had a significant reduction of noise tolerance during the day in contrast with those who slept at night. In addition, noise tolerance seems to be affected by a normal active cortical activity (awake/day) than more slow cortical activity with subcortical modulation (sleep/night). Also, cortical activity seems to play a more important role in hyperacusis than peripheral auditory sensitivity.

Other presentations at the session:

  • Long-Term Dizziness Handicap in Patients with Vestibular Schwannoma: A Multicenter Cross-Sectional Study
  • Vestibular Testing Data in Migraine-Associated Vertigo
  • Dizziness Profile and Clinical Features: A Population Based Survey in Sí£o Paulo City, Brazil
  • Chiari Type I Malformations in Patients with Dizziness
  • Caloric Test and Video-Head-Impulse Test: Usefulness as a Screening Tool of Vestibular Pathology
  • Lateralization Value of Video Head Impulse Test in Peripheral Vestibulopathy: Comparative Study With Caloric Test